ORB

Assassins Creed

Here you can see it sending out energy waves from the Vatican vault

Wrinkle In Time 2003

Halo 4- Cryptum

https://halo.fandom.com/wiki/Cryptum

The Eye of Magnus

https://elderscrolls.fandom.com/wiki/The_Eye_of_Magnus

TMNT

https://tmnt2012series.fandom.com/wiki/Kraang_Communicator

https://tmnt2012series.fandom.com/wiki/The_Kraang

More interesting things here - plan-10-tmnt

https://tmnt2012series.fandom.com/wiki/Technodromes

Marvel Cinematic

https://marvelcinematicuniverse.fandom.com/wiki/Orb

https://marvelcinematicuniverse.fandom.com/wiki/Quest_for_the_Orb

https://marvelcinematicuniverse.fandom.com/wiki/Kree_Orb

Ratchet & Clank Game Series

Biobilterator

https://ratchetandclank.fandom.com/wiki/Biobliterator

> Archon(elongated skull) Mastermind

https://ratchetandclank.fandom.com/wiki/Dr._Nefarious

https://ratchetandclank.fandom.com/wiki/Dimensional_Map

X-Men Cerebro Room

https://en.wikipedia.org/wiki/Cerebro

"Cerebro is a device that fills a massive spherical room"

https://xmenmovies.fandom.com/wiki/Cerebro

Spongebob- Orb of Confusion

https://spongebob.fandom.com/wiki/Orb_of_Confusion

Supergirl-Omegahedron

https://dc.fandom.com/wiki/Omegahedron

Power Rangers

Orb of Doom

https://powerrangers.fandom.com/wiki/Orb_of_Doom

Cosmic Orb

https://powerrangers.fandom.com/wiki/Cosmic_Orbs

Call of Duty

https://callofduty.fandom.com/wiki/Elemental_Orb

https://callofduty.fandom.com/wiki/Vril_Sphere

Fairly Oddparents

" mascot of Brigham Young University's (BYU) " - Cosmo_the_Cougar

Scarlet_Witch - fairlyoddparents/Wanda

Star Trek

https://memory-alpha.fandom.com/wiki/Orb

" The second, the Orb of Peace, was found by Kai Opaka, on a moon in the Gamma Quadrant where she had been marooned since 2369 ("Battle Lines"), and was able to fulfill her goal of ending the conflict between the Ennis and Nol-Ennis trapped there with her."

Adventure Time

https://adventuretime.fandom.com/wiki/Orb

Dragon Orb

https://valkyrieprofile.fandom.com/wiki/Dragon_Orb

Amnesia Game

https://amnesia.fandom.com/wiki/Orb

"the major setting in Amnesia: The Dark Descent, as well as the major setting of all but two stories in the collection Remember." - https://amnesia.fandom.com/wiki/Prussia

There were some key terms used in the pics above :

" Vitae is a mystical substance that is secreted in the blood of humans during times of great stress, such as torture. Alexander of Brennenburg used various methods of torture on prisoners in order to produce the vitae he needed to return his home....Vitae is of cosmic origin and causes the living host to burst with energy. The catalyst is produced somewhere in the brain. Although many of its properties are unknown, one of them is the ability to extend life, potentially for centuries, if consumed in large amounts. In order to procure such amounts, it must be acquired from humans. Alexander found out through torturing dogs " - https://amnesia.fandom.com/wiki/Vitae

" The Machine is the main antagonist of Amnesia: A Machine for Pigs. It was a sprawling network of tunnels and factories situated underneath Victorian London, created by Oswald Mandus, and it gained sentience after part of his soul was inserted. The Machine's malevolent sentience was also referred to as the Engineer...The Machine was created to harvest people and automate human sacrifice on an industrial scale in the hope that it might prevent the horrific events of the 20th century. It was envisioned by Mandus after the disastrous trip to the sacrificial steps of an Aztec temple in Mexico when he came into contact with the Orb. The physical part of the Machine is enormous, stretching far and wide beneath London. The Machine is powered by Compound X, which in turn provides steam for the various machinery. It also produces large amounts of waste that needs to be discharged by a vast system of pumps." - https://amnesia.fandom.com/wiki/The_Machine

Orb of Endless Power

https://dndpodcast.fandom.com/wiki/The_Orb_of_Endless_Power

"One of three artifacts requested by Fennekin. It is located in The Crypt of Sinu the Red."

https://dndpodcast.fandom.com/wiki/The_Crypt_of_Sinu_the_Red

"The Crypt is the supposed final resting place of a powerful wizard named Sinu the Red. It is located in the mountains far to the north of Caer and nobody has seen Sinu in over 500 years. When the gang arrives at the Crypt they find it in an abandoned village with a massive graveyard. The crypt is deep, deep underground. Inside they find the body of Alandar Wyrmsbane and a strange helmet that tests the wearer (with death). The Orb of Endless Power was found here after destroying the rock monster that was guarding it."

https://dndpodcast.fandom.com/wiki/Sinu_the_Red

Data in above example seems very similair to these episode 18/19 form this show :

https://www1.watchcartoononline.bz/episode/justice-league-season-1-episode-18/

https://dcau.fandom.com/wiki/Legends

Orb(Marvel Character)

https://marvel.fandom.com/wiki/Orb_(Mercenary)_(Earth-616)

Energy Orb Half life

https://half-life.fandom.com/wiki/Energy_Ball

Smallville

https://smallville.fandom.com/wiki/Orb

The God Killer

https://dndpodcast.fandom.com/wiki/The_God_Killer

Animator(luck)- Minecraft

https://animatorvsanimation.fandom.com/wiki/Orb

Also see :

https://villains.fandom.com/wiki/Orb_(Animator_vs._Animation)

It's an orb ruling over the dimension inside the Lucky Blocks, which came to life through possessing Yellow's body and seeks to spread chaos throughout the computer, possessing the other stick figures and creating clones of itself to do so. Years later, the Orb returns by hijacking the Lucky Block Staff and attempts to get revenge on the Stick Gang.

He discovers the entry to another dimension, where the Orb is creating everything in the dimension.

the Orb awakens, having hijacked the staff. It constructs a monstrous body for itself

The "host" form the Orb takes upon possessing the staff is a weird, liquid-like blob of constantly changing blocks, never maintaining one stable shape. It can be shapeshifted into looking like anything

Although usually a mindless force of chaos, when it gets to possess someone, the Orb shows itself to be a destructive creature who sadistically takes pride in what its doing, is a show-off who flaunts their skills, and is ready to fight opponents

The Orb shares similarities to the Witch - ("Using her potions, she can become whatever she wants with that thing's powers...She's also sadistic, laughing many times...the Witch appear in a forest after going through the portal. ")

One Piece

https://onepiece.fandom.com/wiki/Orb

" The Evil Guardian is a being created from the hatred of the people on the island in One Piece: Unlimited Adventure. It was a statue of the island's guardian god that was given life by the orb. He serves as the main antagonist of the game.After absorbing the malice of invading pirates and the enemies from the Straw Hat Pirates' memories, the Evil Guardian transformed into the Evil Master Beast.^[1]" - https://onepiece.fandom.com/wiki/Evil_Guardian

Jak Daxter Precursor Orb

https://jakanddaxter.fandom.com/wiki/Precursor_orb